Directly-oral TCMP (Traditional Chinese Medicine Pieces) is novel advanced TCMP recently defined on Pharmaceutical GMP (version 2010) and China Pharmacopoeia (version 2015) Part IV. The products, unlikely as regular TCMP, can be taken orally without decocting. Following the definition of directly-oral TCMP, we have established a new scientific and technological strategy , and methods for the research and development (R & D) of the directly-orally pharmaceutical TCMP products. Our products comply with the regulations of Chinese Food and Drug Administration (CFDA) or provincial FDA, as well as keep the principles of Chinese Traditional Medicine (TCM). Our R & D results indicated that the directly-oral TCMP products, in contrast to regular TCMPs, have significant advantages in non- decocting, keeping TCM original ingredients, improving bioavailability for bioactive constitutes, easy storage, and more safety.